A student of Duilio Cambellotti at the Academy of Fine Arts in Rome, he was a leading exponent of Futurism and had close contacts with representatives of the European artistic avant-garde, with Dadaism with the Section d'Or, the Bauhaus, De Stijl, the Abstraction-Création group, with Pablo Picasso, Piet Mondrian, Wassily Kandinsky and Jean Cocteau, operating theoretically and practically also in the architecture sector.

Exhibition

Enrico Prampolini. Taccuini inediti 1942-1956, Modena, Galleria Civica, Palazzina dei Giardini, 24 November 1991 - 19 January 1992, cat. pp. 201, 202, n. PC 14, illustrated;

Enrico Prampolini, Milano, Arte Centro, November 2002 - January 2003, cat. n. 63, colors illustrated (artwork dated 1949/50).

Studio di copertina per La giostra delle invenzioni (sottotitolo Dalla pietra filosofale alla bomba atomica), di C. L. Andrissi, Enciclopedia delle meraviglie series, Edizioni OET, Roma.